The INSPIRE Project by Healthy Minds Initiative

Community-wide Alzheimer's prevention and lifestyle interventions, through crowd-sourced research

The Problem

Alzheimer’s and others dementias form the fastest-growing epidemic in the world.

90% of cases are preventable, but healthcare resources are often limited or ineffective.

Many communities are under-served by medical research and healthcare policy.

Our Solution

Lifestyle interventions have been shown to counter neurodegenerative diseases.

Our supporters enable us to carry out more of these community projects on a global scale.

By focusing on under-served populations, our work improves healthcare equity.

INSPIRE: Intervention Strategies for Preserving Intellectual Resilience and Engagement

Our Objective

The INSPIRE Project will investigate intervention strategies aimed at preserving intellectual resilience and engagement among underserved populations, with a specific focus on Alzheimer’s prevention and lifestyle interventions.

Project Design

We’ll employ a randomized controlled trial (RCT) design to rigorously evaluate the impact of lifestyle interventions on cognitive outcomes. The project will include intervention and control groups to compare the effects of the interventions against a baseline or standard care condition.

How the INSPIRE Project will work

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INSPIRE Project methodology

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Participant Recruitment

Participants will be recruited from Crenshaw Christian Center, who is partnering with Healthy Minds Initiative. Recruitment efforts will include community outreach and targeted advertising.

Inclusion Criteria

Participants will be adults aged 55 and older, without a diagnosis of dementia but at risk for cognitive decline. They must also be willing to participate in lifestyle intervention programs.

Randomization and Blinding

Participants who meet inclusion criteria will be randomly assigned to either the intervention group or the control group. Randomization will be stratified to ensure balance across key demographics (e.g., age, gender, education level).

Interventions

The intervention group will receive structured lifestyle interventions tailored to Alzheimer’s prevention and cognitive health, including dietary guidance, exercise programs, cognitive training, and social engagement activities. The control group will receive standard care or placebo interventions as appropriate.

Data Collection

Data collection will include baseline assessments (including cognitive tests, medical history, and lifestyle questionnaires) and follow-up assessments at regular intervals (e.g., 6 months, 12 months). Cognitive function will be assessed using validated tools such as Cantab, ensuring standardized and objective measurements.

Statistical Considerations

Statistical analyses will be conducted to compare outcomes between the intervention and control groups. Key statistical considerations include: sample size determination to ensure adequate power to detect meaningful differences, analysis of covariance (ANCOVA), and mixed-effects models.

Ethical Standards and Federal Regulations

The project will adhere to ethical principles outlined in the Belmont Report, including respect for persons, beneficence, and justice. Specific measures to ensure compliance with federal regulations (e.g., HIPAA) and protection of human subjects include:
informed consent processes, Institutional Review Board (IRB) approval, and data security and confidentiality.

Organization of the Project

The project will be led by Healthy Minds Initiative in collaboration with academic researchers, healthcare providers, and community partner, Crenshaw Christian Center. A multidisciplinary team of investigators will oversee project operations. Regular meetings and ongoing communication will facilitate coordination and adherence to project protocols.

In Conclusion:

By adhering to these rigorous protocols and ethical standards, The INSPIRE Project aims to provide valuable insights into effective strategies for preserving intellectual resilience and engagement among underserved populations at risk for Alzheimer’s disease and cognitive decline, which can be standardized and repeated on an international scale.